MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the 12S rRNA gene, regulating metabolic homeostasis via skeletal muscle. Its sequence—MRWQEMGYIFYPRKLR—makes it an exercise mimetic for insulin sensitivity and energy studies.

Peptide Structure

Full sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH (MW 2174.6 Da). MOTS-c translocates to the nucleus under stress, activating AMPK and folate pathways without mitochondrial translation.

Research Benefits

MOTS-c enhances glucose uptake, reduces fat gain, and boosts endurance/physical performance in models. It combats inflammation, supports cardiac health, prevents insulin resistance, and promotes longevity by improving mitochondrial function.

Product Specifications

• Purity: 99%+ HPLC-purified lyophilized powder.

• Form: Synthetic research peptide.

• Dosage Insight: For in-vitro assays; activates AMPK at low doses.

• Storage: -20°C for long-term stability.